children with eczema, Staphylococcus aureus (S. aureus) colonization has
been associated with food sensitization and allergy independent of eczema
study published online in the Journal of Allergy and Clinical Immunology, Olympia
Tsilochristou, M.D., from King’s College London, and colleagues conducted a
secondary analysis to examine the correlation of S. aureuscolonization
with specific immunoglobulin E (sIgE) production to common food allergens and
allergies in early childhood in relation to eczema severity.
Learning Early About Peanut Allergy (LEAP) study, eczema severity was assessed
and skin/nasal swabs were cultured for S. aureus. sIgE levels were
measured to identify sensitization.
researchers found that across the LEAP study, there was a significant
correlation for skin S. aureus colonization with eczema severity; at
12 and 60 months of age, there was a correlation with subsequent eczema
deterioration. At any point in time, skin S. aureus colonization was
associated with elevated levels of hen’s egg white and peanut sIgE, independent
of the severity of eczema.
At 60 and
72 months of age, participants with S. aureus were more likely to
have persistent egg allergy and peanut allergy, independent of eczema severity.
aureus has been implicated in the development and severity of atopic
diseases, namely eczema, allergic rhinitis, and asthma; our findings,” the
authors concluded, “extend these observations to the development of food
allergy independent of eczema severity.”
et al: Association of Staphylococcus
aureus colonization with food allergy occurs independently of eczema