Higher intake of manganese is associated with a lower type 2 diabetes risk among postmenopausal women, independent of known risk factors, the authors of a study published online in Diabetes Care have reported.
Jung Ho Gong, from Brown University in Providence, Rhode Island, and colleagues evaluated the association between manganese intake and the risk for type 2 diabetes in 84,285 postmenopausal women without a history of diabetes participating in the national Women’s Health Initiative Observational Study (WHI-OS). Results were validated in the 62,338 women who participated in the WHI-Clinical Trial (WHI-CT).
The researchers found that compared with the lowest quintile of energy-adjusted dietary manganese, WHI-OS participants in the highest quintile had a lower risk for type 2 diabetes (hazard ratio, 0.70).
These findings were confirmed in the WHI-CT (hazard ratio, 0.79). In a nested case-control study of 3,749 women in the WHI-OS with information on biomarkers of inflammation and endothelial dysfunction, higher energy-adjusted dietary manganese was associated with lower circulating levels of inflammatory biomarkers that significantly mediated the association between dietary manganese and type 2 diabetes risk.
Of type 2 diabetes risk due to manganese, 19 percent of risk was mediated through interleukin 6 and 12 percent through high-sensitivity C-reactive protein.
“Consumption of food groups rich in manganese could potentially be targets for intervention against type 2 diabetes risk in postmenopausal women,” the authors added.
REFERENCE: Gong et al: Dietary Manganese, Plasma Markers of Inflammation, and the Development of Type 2 Diabetes in Postmenopausal Women: Findings From the Women’s Health Initiative; https://care.diabetesjournals.org/content/early/2020/04/14/dc20-0243