A new study shows that elderly people who have been admitted to an intensive care units have less risk of dying and of suffering a blood clot or bleeding in the brain if they have been vaccinated according to a study published in Intensive Care Medicine.
In this study, researchers assessed data on 89 818 ICU survivors from the Danish Intensive Care Database data on all elderly (65 and older) patients hospitalised in Danish ICUs from 2005–2015, and subsequently discharged. They linked data from other medical registries, focusing on data regarding seasonal influenza vaccinations. Of the total study population, 39% (n=34 871) were influenza vaccinated, and this group was older, had more chronic diseases, and used more prescription medications than the unvaccinated group. The researchers computed these patients’ one-year risk of hospitalisation for myocardial infarction, stroke, heart failure, or pneumonia, as well as their one-year risk of all-cause mortality. They then computed hazard ratios (HRs) with 95% confidence intervals (CIs) using Cox proportional hazards regression.
Following data analysis, the results showed that adjusted one-year mortality decreased among the vaccinated patients compared to unvaccinated patients (19.3% versus 18.8%, respectively; adjusted HR, 0.92; 95% CI 0.89 to 0.95). Influenza vaccinated patients also had a decreased risk of stroke (adjusted HR=0.84; 95% CI 0.78 to 0.92), but a minimal, non-significant risk of myocardial infarction (adjusted HR= 0.93; 95% CI 0.83 to 1.03). Moreover, the study found no discernible link between vaccination and subsequent hospitalisation for heart failure or pneumonia.
Reference: Fynbo Christianse C, et al. Influenza vaccination and 1-year risk of myocardial infarction, stroke, heart failure, pneumonia, and mortality among intensive care unit survivors aged 65 years or older: a nationwide population-based cohort study. Intensive Care Medicine. July 2019, Volume 45, Issue 7, pp 957–967